Association of ADAM 33 Gene Polymorphisms with Keloid Scars in a Northeastern Chinese Population

作者：Han Jianyu; Han Jianfeng; Yu Dongmei; Xiao Jinling; Shang Yong; Hao Lijun^*

来源：Cellular Physiology and Biochemistry, 2014, 34(3): 981-987.

DOI：10.1159/000366314

• Keloid scar
• ADAM33
• Single nucleotide polymorphism
• Association study

Objective: To study the association between ADAM33 and keloid scars in the northeastern Chinese population. Methods: A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Results: We observed the frequency of the rs612709 A allele exhibited a significantly decreased frequency in cases than in controls(22 vs.39.6%, P<0.0001) We also found that the frequencies of H2 (GGAAGA) haplotypes was significantly higher in the case group than in the control group (P=0.041). In contrast, the haplotype H8 (GGGAGG) was more common in the control group than in the case group (P=0.022). Conclusions: Our data suggest that the ADAM33 polymorphisms may be associated with keloid scars in the northeastern Chinese population.

• 出版日期2014
• 单位哈尔滨医科大学