Antimicrobial activity of cis-[Ru(bpy)(2)(L)(L ')](n+) complexes, where L=4-(4-chlorobenzoyl)pyridine or 4-(benzoyl)pyridine and L ' = Cl- or CO

作者：de Sousa Aurideia P; Ellena Javier; Gondim Ana C S; Lopes Luiz G F; Sousa Eduardo H S; de Vasconcelos Mayron A; Teixeira Edson H; Ford Peter C; Holanda Alda K M^*

来源：Polyhedron, 2018, 144: 88-94.

DOI：10.1016/j.poly.2018.01.002

• Ruthenium complexes
• Nucleobases
• Photochemical
• Antibacterial drugs
• Metallodrugs

The cis-(Ru(bpy)(2)(clbzpy)(Cl)](PF6) complex (I), where clbzpy = 4-(4-chlorobenzoyl)pyridine and bpy = 2,2'-bipyridine, was prepared and fully characterized. Blue light photolysis (453 nm) of this compound in aqueous solution led to release of clbzpy and formation of the cis-[Ru(bpy)(2)(H2O)Cl](+) ion, as supported by NMR and electronic spectroscopy. The latter photoproduct is shown to subsequently interact with DNA. We also describe the antimicrobial activity of the compound I against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa and compares with the activity of analogous compounds, cis-[Ru(bpy)(2)(4-bzpy)(Cl)](PF6) (II) and cis-[Ru(bpy)(2)(4-bzpy)(CO)](PF6) (III), where 4-bzpy = 4-benzoylpyridine. Compounds I and II showed moderate activity against the gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis. However, compound III did not. None of the three compounds showed activity against gram-negative Pseudomonas aeruginosa. Notably, blue light irradiation of I or II did not promote any major changes in the antimicrobial activity, thus we propose that the antimicrobial activity is not related to DNA damage, but might be associated to bacterial membrane disruption.

• 出版日期2018-4-1