Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine

作者：Remichkova Mimi; Dimitrova Petya; Philipov Stefan; Ivanovska Nina^*

来源：Fitoterapia, 2009, 80(7): 411-414.

DOI：10.1016/j.fitote.2009.05.016

• Glaucine
• Oxoglaucine
• Toll-like receptors
• Macrophages
• Cytokines
• Nitric oxide

Two isochinoline alkaloids, glaucine and oxoglaucine were investigated for their suggested anti-inflammatory influence concerning nitric oxide and cytokine production. Mouse peritoneal macrophages were stimulated with different Toll-like receptor (TLR) ligands such as LPS for TLR4, zymosan for TLR2 and CpG for TLR9. The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands. In regard to IL-12 suppressive effect was registered in the case of CpG stimulation. Glaucine succeeded to enhance LPS and zymosan-induced IL-10 production. The reduction of pro-inflammatory cytokines and increase of anti-inflammatory IL-10 are indicative for their use in different acute and chronic inflammatory diseases.

• 出版日期2009-10