Novel Efficient Routes to Indoxyl Glycosides for Monitoring Glycosidase Activities

作者：Boettcher Stephan; Hederos Markus; Champion Elise; Dekany Gyula; Thiem Joachim^*

来源：Organic Letters, 2013, 15(14): 3766-3769.

DOI：10.1021/ol401710a

A new efficient synthesis for broad access to indoxyl glycosides was developed. Indoxylic acid allyl ester linked to a sugar structure served as the key intermediate in this route. Selective ester cleavage and mild decarboxylation led to the corresponding indoxyl glycosides in good yields. This synthesis was applied for preparation of indoxyl glycosides of fucose, sialic acid, and 6%26apos;-sialyl lactose.

• 出版日期2013-7-19