Alum catalyzed simple and efficient synthesis of 5-arylidene-2,4-thiazolidinedione in aqueous media

作者：Shelke Kiran F; Sapkal Suryakant B; Kakade Gopal K; Sadaphal Sandip A; Shingate Bapurao B; Shingare Murlidhar S^*

来源：Green Chemistry Letters and Reviews, 2010, 3(1): 17-21.

DOI：10.1080/17518250903478345

• Knoevenagel condensation
• alum
• 2,4-thiazolidinedione
• aromatic aldehyde
• aqueous media

Alum (KAl(SO(4))(2)center dot 12H(2)O) is an inexpensive, efficient, and non-toxic catalyst used for the synthesis of 5-arylidine-2,4-thiazolidinediones by the Knoevenagel condensation of aromatic aldehydes with 2,4-thiazolidinedione in aqueous media at 90 degrees C. This method affords the 5-arylidine-2,4-thiazolidinediones in short reaction times, high yields, and green aspects by avoiding toxic catalysts and hazardous solvents.

• 出版日期2010