A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women

作者：Gepner Adam D; Haller Irina V; Krueger Diane C; Korcarz Claudia E; Binkley Neil; Stein James H^*

来源：Atherosclerosis, 2015, 240(2): 526-528.

DOI：10.1016/j.atherosclerosis.2015.04.795

• Arterial stiffness
• Vitamin D
• Central blood pressure
• Cardiovascular disease risk

Objective: It is unclear if vitamin D supplementation improves central blood pressure or arterial stiffness in Native American (NA) women.
Methods: Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP) and aortic augmentation index (AIx) were estimated by tonometry at baseline and after 6 months.
Results: Study volunteers (n = 98) were 61 (7.3) years old. 25(OH) D was 26.4 (11.0) ng/ mL. 25(OH) D was similar between the two treatment groups (p = 0.291), as were baseline cSBP, cPP, and CVD risk factors (all p > 0.1). Treatment with 2500 IU of daily vitamin D3 did not affect cSBP, cPP, or AIx (all p > 0.1) compared to 400 IU daily.
Conclusions: Despite low serum 25(OH) D at baseline, 6 months of vitamin D supplementation did not improve central blood pressure parameters or arterial stiffness in NA women.

• 出版日期2015-6