High-Dose Daptomycin plus Fosfomycin Is Safe and Effective in Treating Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Endocarditis

作者：Miro Jose M^*; Entenza Jose M; del Rio Ana; Velasco Maria; Castaneda Ximena; Garcia de la Maria Cristina; Giddey Marlyse; Armero Yolanda; Pericas Juan M; Cervera Carlos; Mestres Carlos A; Almela Manuel; Falces Carlos; Marco Francesc; Moreillon Philippe; Moreno Asuncion

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(8): 4511-4515.

DOI：10.1128/AAC.06449-11

We describe 3 patients with left-sided staphylococcal endocarditis (1 with methicillin-susceptible Staphylococcus aureus [MSSA] prosthetic aortic valve endocarditis and 2 with methicillin-resistant S. aureus [MRSA] native-valve endocarditis) who were successfully treated with high-dose intravenous daptomycin (10 mg/kg/day) plus fosfomycin (2 g every 6 h) for 6 weeks. This combination was tested in vitro against 7 MSSA, 5 MRSA, and 2 intermediately glycopeptide-resistant S. aureus isolates and proved to be synergistic against 11(79%) strains and bactericidal against 8 (57%) strains. This combination deserves further clinical study.

• 出版日期2012-8