摘要
To determine the optimum treatment for viral myocarditis (VMC). A total of 126 VMC patients were randomly divided into the control group (42 cases) that was treated with conventional Western medicine, and the intervention group (84 cases) that was treated with a combination of Chinese medicine (CM) and Western medicine intervention termed optimum proposal of integration of disease and syndrome (OPIDS). Before and after 4 weeks of treatment, the integral of CM syndrome, self-rating depression and anxiety scales (SDS and SAS, respectively), echocardiograms (ECGs), heart rate variability and left ventricular systolic function were observed. Compared with the control group, the intervention group showed significant reductions on the SDS and SAS (P < 0.05); improvement of premature ventricular beats, atrioventricular blocks, ST-segment abnormalities, and significant T wave changes (P < 0.05); greater reductions in standard deviation of NN intervals (SDNN), standard deviation for per 5 min averages NN intervals (SDANN), and root-mean-square of successive difference of NN intervals (rMSSD) (P < 0.05); and increases in cardiac output, stroke volume, and ejection fraction, the last of which was statistically significant (P < 0.05). Overall, the treatment efficacy rate was significantly better P < 0.05) in the intervention group (75.61%) compared with the control group (69.70%). OPIDS is quite effective in treating VMC and improves symptoms such as anxiety and depression, left ventricular systolic dysfunction, premature ventricular contraction, and cardiac autonomic nervous system dysfunction. [Registration: Chinese clinical trial center (No. ChiCTR-TRC-00000298)].
- 出版日期2015-3
- 单位天津中医药大学