A new selective turn-on fluorogenic dipodal-cobalt(II) ensemble probe for nitrite ion detection and live cell imaging

作者：Mahapatra Ajit Kumar^*; Hazra Giridhari; Mukhopadhyay Subhra Kanti; Mukhopadhyay Anindita Roy

来源：Tetrahedron Letters, 2013, 54(9): 1164-1168.

DOI：10.1016/j.tetlet.2012.12.083

• Dipodal-triazole-Co2+-ensemble
• PET sensor
• Quinoline
• Nitrite ion
• Living cells

A new dipodal-triazole-Co2+-ensemble with a ligand containing quinoline moiety was designed and synthesized as a highly sensitive fluorescent sensor for nitrite in aqueous media. Based on in situ-formed Co2+-DTQ (Co2+ chelated dipodal of triazole-quinoline) ensembles having the specific binding affinity for nitrite anions over other anions, this sensory system allows rapid recognition and quantitative detection of nitrite in neutral aqueous media in an 'off-on' fashion. To confirm the suitability of DTQ for biological applications, we also employed it for the fluorescence detection of the changes of intracellular NO2- in three different species of cultured cells in the presence of nitrite ions.

• 出版日期2013-2-27