Autologous melanocyte-keratinocyte suspension in the treatment of vitiligo

作者：El Zawahry B M; Zaki N S; Bassiouny D A^*; Sobhi R M; Zaghloul A; Khorshied M M; Gouda H M

来源：Journal of the European Academy of Dermatology and Venereology, 2011, 25(2): 215-220.

DOI：10.1111/j.1468-3083.2010.03759.x

• autologous
• keratinocytes
• melanocytes
• transplantation
• vitiligo

Background
In stable vitiligo, several techniques of autologous transplantation of melanocytes are used. Autologous melanocyte transplantation of non-cultured melanocytes is one of those techniques with variable reported outcomes.
Objective
The objective of this study was to evaluate the response to autologous melanocyte-keratinocytes suspension transplantation in cases of stable vitiligo.
Methods
A total of 25 cases of vitiligo were treated by autologous melanocyte-keratinocytes suspension transplantation. After 6-17 months, patients' response was evaluated according to the extent of pigmentation (excellent 90-100%, good 50-89%, fair 20-49% and poor response < 20%).
Results
Of the 25 patients treated, 22 continued the follow-up period. Five (23%) patients showed excellent response, 7 (32%) good, 6 (27%) fair and 4(18%) showed poor response.
Conclusion
Unlike transplantation of cultured melanocytes, which requires experience in culture technique, autologous melanocyte-keratinocytes suspension transplantation is an easy economic technique, which may be used in resistant areas of stable vitiligo.

• 出版日期2011-2