A novel predictor for protein structural class based on integrated information of the secondary structure sequence

作者：Zhang Lichao; Zhao Xiqiang^*; Kong Liang; Liu Shuxia

来源：Biochimie, 2014, 103C: 131-136.

DOI：10.1016/j.biochi.2014.05.008

• Sequence similarity
• Protein structural class
• Support vector machine
• Position of alpha-helices and beta-strands

The structural class has become one of the most important features for characterizing the overall folding type of a protein and played important roles in many aspects of protein research. At present, it is still a challenging problem to accurately predict protein structural class for low-similarity sequences. In this study, an 18-dimensional integrated feature vector is proposed by fusing the information about content and position of the predicted secondary structure elements. The consistently high accuracies of jackknife and 10-fold cross-validation tests on different low-similarity benchmark datasets show that the proposed method is reliable and stable. Comparison of our results with other methods demonstrates that our method is an effective computational tool for protein structural class prediction, especially for low-similarity sequences.

• 出版日期2014-8
• 单位河北科技师范学院; 中国海洋大学