Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy

作者：Pramanik Rocky; Sheng Xia; Ichihara Brian; Heisterkamp Nora; Mittelman Steven D^*

来源：Leukemia Research, 2013, 37(5): 503-509.

DOI：10.1016/j.leukres.2012.12.013

• Adipocytes
• Acute lymphoblastic leukemia
• ALL
• AMD3100
• C-X-C chemokine receptor type 4
• CXCR4
• Microenvironment
• SDF-1 alpha, stromal derived-factor-1 alpha

Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1 alpha. In addition, adipose tissue explants protected ALL cells against daunorubicin and vincristine. Our findings suggest that ALL migration into adipose tissue could contribute to drug resistance and potentially relapse.

• 出版日期2013-5