A novel 2-(Hydroxymethyl)quinolin-8-ol-based selective and sensitive fluorescence probe for Cd2+ ion in water and living cells

作者：Dai, Yanpeng; Yao, Kun; Fu, Jiaxin; Xue, Kun; Yang, Li; Xu, Kuoxi^*

来源：Sensors and Actuators B: Chemical , 2017, 251: 877-884.

DOI：10.1016/j.snb.2017.05.103

• Quinolone
• Fluorescent probe
• Pure water
• Cd2+

A novel probe 1a based on hydroxymethylquinolin-8-ol was designed and synthesized. Probe 1a exhibited "turn-on" fluorescence response for Cd2+ ion over other ions in aqueous solutions (almost 100% water). The association constants of probe 1a toward Cd2+ ion were found to be 9.00 x 10(4) M-1 by Benesi-Hildebrand equation (R-2= 0.9995) and the limit of detection was calculated to be 1.18 x 10(-6) M. The mechanism of the complexation of 1a with Cd2+ had been studied by H-1 NMR, ESI-MS, FT-IR and X-ray crystal. Furthermore, in studies with living cells, probe 1a was almost no toxicity, cell-membrane-permeable and could be used to monitor Cd2+ ion in living cells.

• 出版日期2017-11
• 单位河南大学