Association of Smoking and Other Risk Factors With Fuchs%26apos; Endothelial Corneal Dystrophy Severity and Corneal Thickness

作者:Zhang Xiaolin; Igo Robert P Jr; Fondran Jeremy; Mootha V Vinod; Oliva Matt; Hammersmith Kristin; Sugar Alan; Lass Jonathan H; Iyengar Sudha K*
来源:INVESTIGATIVE OPHTHALMOLOGY %26 VISUAL SCIENCE, 2013, 54(8): 5829-5835.
DOI:10.1167/iovs.13-11918

摘要

PURPOSE. We investigated effects of smoking and other risk factors on the development of advanced Fuchs%26apos; endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT). %26lt;br%26gt;METHODS. Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT. %26lt;br%26gt;RESULTS. In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 mu m in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 mu m (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 mu m). %26lt;br%26gt;CONCLUSIONS. Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.

  • 出版日期2013-8