Mirror image phage display - Generating stable therapeutically and diagnostically active peptides with biotechnological means

作者：Sun Na; Funke Susanne Aileen; Willbold Dieter^*

来源：Journal of Biotechnology, 2012, 161(2): 121-125.

DOI：10.1016/j.jbiotec.2012.05.019

• Mirror image phage display
• D-enantiomeric peptide
• Pharmaceutical biotechnology
• Drug discovery

Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches.

• 出版日期2012-10-15