A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis

作者：Terashima Kazuki^*; Demizu Yusuke; Hashimoto Naoki; Jin Dongcun; Mima Masayuki; Fujii Osamu; Niwa Yasue; Takatori Kento; Kitajima Naoto; Sirakawa Sachiyo; Yonson Ku; Hishikawa Yoshio; Abe Mitsuyuki; Sasaki Ryohei; Sugimura Kazuro; Murakami Masao

来源：Radiotherapy and Oncology, 2012, 103(1): 25-31.

DOI：10.1016/j.radonc.2011.12.029

• Proton radiotherapy
• Gemcitabine
• Pancreatic cancer
• Locally advanced
• Chemoradiotherapy

Purpose: We conducted the study to assess the feasibility and efficacy of gemcitabine-concurrent proton radiotherapy (GPT) for locally advanced pancreatic cancer (LAPC). %26lt;br%26gt;Materials and methods: Of all 50 patients who participated in the study, 5 patients with gastrointestinal (GI)-adjacent LAPC were enrolled in P-1 (50 Gy equivalent [GyE] in 25 fractions) and 5 patients with non-GI-adjacent LAPC in P-2 (70.2 GyE in 26 fractions), and 40 patients with LAPC regardless of GI-adjacency in P-3 (67.5 GyE in 25 fractions using the field-within-a-field technique). In every protocol, gemcitabine (800 mg/m(2)/week for 3 weeks) was administered concurrently. Every patient received adjuvant chemotherapy including gemcitabine after GPT within the tolerable limit. %26lt;br%26gt;Results: The median follow-up period was 12.5 months. The scheduled GPT was feasible for all except 6 patients (12%) due to acute hematologic or Cl toxicities. Grade 3 or greater late gastric ulcer and hemorrhage were seen in 5 patients (10%) in P-2 and P-3. The one-year freedom from local-progression, progression-free, and overall survival rates were 81.7%, 64.3%, and 76.8%, respectively. %26lt;br%26gt;Conclusion: GPT was feasible and showed high efficacy. Although the number of patients and the follow-up periods are insufficient, the clinical results seem very encouraging.

• 出版日期2012-4