Anthracycline antibiotics and their derivatives, inhibitors of topoisomerase I

作者:Dezhenkova L G*; Tevyashova A N; Sureva E N; Treshchalin I A; Shfil A A; Preobrazhenskaya M N
来源:Russian Journal of Bioorganic Chemistry, 2008, 34(3): 387-389.
DOI:10.1134/S1068162008030230

摘要

The relationship between the structure of new semisynthetic derivatives of doxorubicin, daunorubicin, and carminomycin and their ability to inhibit topoisomerase I were studied. The new derivatives inhibit the activity of topoisomerase I at low concentrations, induce the death of K-562 leukemia cells in culture, and produce an antitumor effect in experimental animals bearing P388 leukemia.

  • 出版日期2008-6