Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure

作者：Pfaender Stephanie; Walter Stephanie; Todt Daniel; Behrendt Patrick; Doerrbecker Juliane; Woelk Benno; Engelmann Michael; Gravemann Ute; Seltsam Axel; Steinmann Joerg; Burbelo Peter D; Klawonn Frank; Feige Karsten; Pietschmann Thomas; Cavalleri Jessika M V; Steinmann Eike

来源：Journal of General Virology, 2015, 96(9): 2636-2642.

DOI：10.1099/vir.0.000208

The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.

• 出版日期2015-9
• 单位河北医科大学; NIH