Are subjective cognitive complaints a risk factor for dementia?

作者：Gallassi Roberto^*; Oppi Federico; Poda Roberto; Scortichini Simona; Maserati Michelangelo Stanzani; Marano Gianfranco; Sambati Luisa

来源：Neurological Sciences, 2010, 31(3): 327-336.

DOI：10.1007/s10072-010-0224-6

• Memory
• Mild cognitive impairment
• Neuropsychological tests
• Subjective cognitive complaints

The objective is to evaluate the prognosis of subjective cognitive complaints (SCC) patients during 4-year follow-up. A prospective study on 92 SCC patients investigating their cognitive, affective and behavioural aspects. SCC patients were classified as having no objective cognitive impairment (NOCI), mild cognitive impairment (MCI), or subtypes of MCI. Results: 43 patients were found to have NOCI and 49 MCI. During the follow-up, 45.5% of NOCI patients remained unchanged, 13.9% were diagnosed as MCI and only one progressed to dementia. Of the MCI patients, 32.3% remained stable, 18.4% became demented and 4% reverted to NOCI. Visual attention, behavioural memory, long-term verbal memory, apathy and caregiver distress, provided independent predictors of progression to dementia.

• 出版日期2010-6