Asymmetric Reduction of 2-Chloro-3-oxo Esters by Transfer Hydrogenation

作者：Bai Jinjin; Miao Shifeng; Wu Yun; Zhang Yawen^*

来源：Chinese Journal of Chemistry, 2011, 29(11): 2476-2480.

DOI：10.1002/cjoc.201180419

• asymmetric catalysis
• transfer
• hydrogenation
• 2-chloro-3-oxo esters
• ruthenium

Asymmetric reduction of 2-chloro-3-oxo esters was achieved by catalytic transfer hydrogenation using [RuCl2(p-cymene)](S,S)-TsDPEN as the chiral catalyst and HCOOH-Et3N as the hydrogen source. Moderate to good yields (up to 85%) and good enantioselectivities (up to 98% ee) were obtained.

• 出版日期2011-11
• 单位苏州大学