Antithrombogenic properties of a nitric oxide-releasing dextran derivative: evaluation of platelet activation and whole blood clotting kinetics

作者：Damodaran Vinod B; Leszczak Victoria; Wold Kathryn A; Lantvit Sarah M; Popat Ketul C; Reynolds Melissa M^*

来源：RSC Advances, 2013, 3(46): 24406-24414.

DOI：10.1039/c3ra45521a

Controlling platelet activation and clotting initiated by cardiovascular interventions remains a major challenge in clinical practice. In this work, the antithrombotic properties of a polysaccharide-based nitric oxide (NO)-releasing dextran derivative are presented. Total platelet adhesion, platelet morphology and whole blood clotting kinetics were used as indicators to evaluate the anticlotting properties of this material. With a total NO delivery of 0.203 +/- 0.003 mu mol, the NO-releasing dextran derivative (Dex-SNO) mixed with blood plasma demonstrated a significantly lower amount of platelet adhesion and activation onto a surface and reduced whole blood clotting kinetics. Nearly 75% reduction in platelet adhesion and a significant retention of platelet morphology were observed with blood plasma treated with Dex-SNO, suggesting this to be a potential antiplatelet therapeutic agent for preventing thrombosis that does not have an adverse effect on circulating platelets.

• 出版日期2013