Asymmetric Substitution at the Tetrasubstituted Chiral Carbon: Catalytic Ring-Opening Alkylation of Racemic 2,2-Disubstituted Aziridines with 3-Substituted Oxindoles

作者：Ohmatsu Kohsuke; Ando Yuichiro; Ooi Takashi^*

来源：Journal of the American Chemical Society, 2013, 135(50): 18706-18709.

DOI：10.1021/ja411647x

A highly diastereo- and enantioselective ring-opening alkylation of racemic 2,2-disubstituted aziridines with 3-substituted oxindoles is achieved under the catalysis of a chiral 1,2,3-triazolium salt. This reaction represents a hitherto unknown, catalytic stereoselective carbon carbon bond formation through direct substitution at the tetrasubstituted chiral carbon.

• 出版日期2013-12-18