Discovery of Hypoiodite-Mediated Aminyl Radical Cyclization Lacking a Nitrogen Radical-Stabilizing Group: Application to Synthesis of an Oxazaspiroketal-Containing Cephalostatin Analog

作者：Koag Myong; Lee Seongmin^*

来源：Organic Letters, 2011, 13(18): 4766-4769.

DOI：10.1021/ol2017033

Synthesis of an oxazaspiroketal-containing bissteroidal pyrazine is described. The key transformation of this synthesis involves stereoselective formation of oxazaspiroketal via aminyl-radical cyclization of primary amine lacking a radical-stabilizing group by Suarez hypoiodite oxidation.

• 出版日期2011-9-16