An Efficient Protocol for the Synthesis of Primary Amides via Rh-Catalyzed Rearrangement of Aldoximes

作者：Xu, Fen^*; Song, Yuan-Yuan; Li, Yan-Jie; Li, Er-Long; Wang, Xin-Ran; Li, Wen-Yue; Liu, Chun-Sen^*

来源：ChemistrySelect, 2018, 3(12): 3474-3478.

DOI：10.1002/slct.201800265

• Amides
• Catalysis
• Oximes
• Rearrangement
• Rhodium

A system consisting of catalytic amounts of [Rh(CH2 = CH2)Cl](2)/PPh2Cy, and PhCl as the solvent efficiently catalyzes selective rearrangement of aldoximes to furnish various primary amides in moderate to good yields. Replacing the [Rh(CH2 = CH2)Cl](2) with Rh(NBD)(2)OTf enables the superior transformation to afford the amides with up to 99% yields. Attractive synthetic features associated with this methodology include absence of co-catalysts, broad functional group tolerance, good to excellent yields, low metal loadings, and operational convenience.

• 出版日期2018-3-29
• 单位郑州轻工业大学