Building Biomedical Materials using Photochemical Bond Cleavage

作者：Bao Chunyan; Zhu Linyong^*; Lin Qiuning; Tian He

来源：Advanced Materials, 2015, 27(10): 1647-1662.

DOI：10.1002/adma.201403783

• Bioactive molecules
• Biomedical applications
• Biomedical material
• Bond cleavages
• Living systems
• Photo activations
• Photo-responsive
• Photolysis reaction

Light can be used as an external trigger to precisely determine where and when a process is initiated as well as how much of the process is being consumed. Phototriggers are a type of photoresponsive functional group that undergo an irreversible photolysis reaction by selectively breaking a chemical bond, enabling three fundamental functions: the photoactivation of fluorescent and bioactive molecules; the photocleavable degradation of macromolecular materials; and the photorelease of drugs, active groups, or surface charges from carriers and interfaces. With the expanded applications of light-controlled technology, particularly in living systems, new challenges and improvements of phototriggers are required to fulfill the demands for better sensitivity, faster kinetics, and more-demanding biomedical applications. Here, improvements to several conventional phototriggers are highlighted, and their notable, representative biomedical applications and their challenges are discussed.

• 出版日期2015-3-11
• 单位华东理工大学