Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model

作者：Kim In Cheol; Nam Chang Wook^*; Cho Yun Kyeong; Park Hyoung Seob; Yoon Hyuck Jun; Kim Hyungseop; Chung In Sung; Han Seongwook; Hur Seung Ho; Kim Yoon Nyun; Kim Kwon Bae

来源：International Journal of Cardiology, 2016, 221: 860-866.

DOI：10.1016/j.ijcard.2016.07.080

• Frequency domain optical coherence tomography
• Intravascular ultrasound
• Size discrepancy

Background: This purpose of this study is to evaluate, concomitantly with quantitative coronary angiography (QCA), the potential discrepancy between frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) measurements in a phantom coronary model and in human coronary arteries within and outside stented segments.
Methods: FD-OCT and IVUS images sequentially obtained from a phantom coronary model and 57 stented human coronary arteries were compared between each other and with QCA.
Results: Lumen area (LA) by IVUS was 10.1% larger (6.43 +/- 0.09 mm(2)) while by FD-OCT was similar (5.78 +/- 0.09 mm(2)) to actual phantom LA (5.72 mm(2)); IVUS vs. FD-OCT stent area (SA) was 4.2% larger. In human coronary artery, diameter by QCA was smaller than by IVUS and OCT in reference (by 10.5% and 3.5%, both p < 0.001) and stented (3.6%, p < 0.001; and 1.7%, p - 0.012) segments. IVUS vs. FD-OCT distal reference LA was significantly larger (6.19 +/- 2.18 mm(2) vs. 5.49 +/- 2.49 mm(2), p < 0.001, respectively), and SA was numerically larger (7.42 +/- 2.28 mm(2) vs. 7.22 +/- 2.48 mm(2), p = 0.059) with larger discrepancy in reference (11.3%) than stented (2.7%) segments. IVUS vs. FD-OCT correlation for diameter was significantly higher for stented than reference segments (R-2 = 0.8670 vs. 0.7351, p = 0.047), while numerically higher for area (R-2 = 0.8663 vs. 0.7806, p = 0.157).
Conclusions: In phantom model and human coronary arteries, IVUS vs. FD-OCT measurements were larger, particularly in non-stented than stented segments, and diameter was smaller by QCA vs. IVUS or FD-OCT. Despite undefined clinical significance, said discrepancy warrants consideration.

• 出版日期2016-10-15