Monitoring of Motor Disorders in 7-Day-Old Rats with Severe Hypoxic-Ischemic Injury of the Brain

作者:Karasev A V; Lebedev S V*; Garats T V; Sharibzhanova A M; Makarov A V; Volodin N N; Chekhonin V P
来源:Bulletin of Experimental Biology and Medicine, 2010, 149(6): 677-681.
DOI:10.1007/s10517-010-1022-0

摘要

Seven-day old rats were subjected to unilateral ligation of the common carotid artery followed by 2-h exposure to a gas mixture consisting of 8% oxygen and 92% nitrogen. Locomotor function of rats was monitored weekly. Functional deficit in these animals persisted for at least 3 months. The exercise tests of rotarod, hanging, and narrowing track were most informative. Our results can be used in preclinical studies of new drugs for the therapy of perinatal brain injury.

  • 出版日期2010-11