科研之友
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摘要
An alkali-metal promoted cycloisomerization reaction of 2-alkynylbenzamides is described for the synthesis of useful (Z)-3-alkylideneisoindolin-1-one derivatives in modest to good yields and excellent chemo- and regioselectivity. Superstoichiometric amounts of water was found to be crucial for this reaction, and no transition-metal salts are necessary. This synthetically green protocol proceeds efficiently with 100% atom economy and tolerates a diverse number of functional groups.
- 出版日期2018-4-9
- 单位江西师范大学
