Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis

作者：Harvey D; Pointon J J; Sleator C; Meenagh A; Farrar C; Sun J Y; Senitzer D; Middleton D; Brown M A; Wordsworth B P^*

来源：Annals of the Rheumatic Diseases, 2009, 68(4): 595-598.

DOI：10.1136/ard.2008.095927

Objectives: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS).
Methods: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the x 2 test.
Results: KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls.
Conclusions: Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.

• 出版日期2009-4