Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine

作者：Onoshima Daisuke^*; Yukawa Hiroshi; Baba Yoshinobu

来源：Advanced Drug Delivery Reviews, 2015, 95: 2-14.

DOI：10.1016/j.addr.2015.08.004

• Quantum dots
• FRET
• Microfluidic device
• Cancer diagnosis
• Stem cell labeling
• Cationic liposomes
• Cell-penetrating peptides
• Cell transplantation

A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs). QDs have developed into new formats of biomolecular sensing to push the limits of detection in biology and medicine. QDs can be also utilized as bio-probes or labels for biological imaging of living cells and tissues. More recently, QDs has been demonstrated to construct a multifunctional nanoplatform, where the QDs serve not only as an imaging agent, but also a nanoscaffold for diagnostic and therapeutic modalities. This review highlights the promising applications of multi-functionalized QDs as advanced nanosensors for diagnosing cancer and as innovative fluorescence probes for in vitro or in vivo stem cell imaging in regenerative medicine.

• 出版日期2015-12-1