Tolerogenic insulin peptide therapy precipitates type 1 diabetes

作者：Bergman Marie Louise; Lopes Carvalho Thiago; Martins Ana Catarina; Grieco Fabio A; Eizirik Decio L; Demengeot Jocelyne^*

来源：Journal of Experimental Medicine, 2017, 214(7): 2153-2156.

DOI：10.1084/jem.20160471

<jats:p>Daniel et al. (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.1084/jem.20110574" ext-link-type="uri">https://doi.org/10.1084/jem.20110574</jats:ext-link>) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.</jats:p>

• 出版日期2017-7