Antigens for CD4 and CD8 T Cells in Tuberculosis

作者：Arlehamn Cecilia S Lindestam; Lewinsohn David; Sette Alessandro; Lewinsohn Deborah

来源：Cold Spring Harbor Perspectives in Medicine, 2014, 4(7): a018465.

DOI：10.1101/cshperspect.a018465

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II-restricted CD4(+) and CD8(+) T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4(+) and CD8(+) T cells show extensive breadth and diversity in MTB-infected humans.

• 出版日期2014-7