A simple and efficient synthesis of pyrazoles in water

作者:Wen Jun; Fu Yun; Zhang Ruo Yi; Zhang Ji*; Chen Shan Yong; Yu Xiao Qi
来源:Tetrahedron, 2011, 67(49): 9618-9621.
DOI:10.1016/j.tet.2011.09.074

摘要

A simple, highly efficient, and environmentally friendly method for the synthesis of substituted 1H-pyrazoles by one-pot condensation reaction of alpha,beta-unsaturated carbonyl compounds with tosyl hydrazide in water was developed. The reaction system exhibited tolerance with various functional groups, Aromatic moiety with both electron-rich and electron-deficient substituents could give desired products in good to excellent yields.