Activation mechanisms for pseudomonas species lipase by cardiovascular drugs in vitro

作者：Lin Ming Cheng; Laib Gin Win; Lin Chung Sheng; Lin Gialih^*

来源：Journal of the Chinese Chemical Society, 2007, 54(6): 1601-1606.

• lipase
• enzyme kinetics
• cardiovascular drug
• enzyme activation

The goal of this work was to determine the reaction mechanism for Pseudomonas species lipase activation by cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride based on the results from enzyme kinetics. These drugs are the essential activators of Pseudomonas species lipase in the presence of triton-X 100 or taurochloate in vitro. Moreover, QSAR studies show that the pK(A) values are correlated with the molecular weights of these drugs.

• 出版日期2007-12
• 单位河北医科大学