A knowledgebase resource for interleukin-17 family mediated signaling

作者：Sharma Jyoti; Balakrishnan Lavanya; Datta Keshava K; Sahasrabuddhe Nandini A; Khan Aafaque Ahmad; Sahu Apeksha; Singhal Anish; Getnet Derese; Raju Rajesh; Chatterjee Aditi; Gowda Harsha; Prasad T S Keshava; Shankar Subramanian^*; Pandey Akhilesh

来源：Journal of Cell Communication and Signaling, 2015, 9(3): 291-296.

DOI：10.1007/s12079-015-0297-3

• Activation
• Differential expression
• Inhibition
• NetPath
• Post-translational modifications
• Protein-protein interaction
• Translocation

Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.

• 出版日期2015-9