Antioxidant Activity of Nepeta nuda L. ssp. nuda Essential Oil Rich in Nepetalactones from Greece

作者：Gkinis George; Bozin Biljana; Mimica Dukic Neda; Tzakou Olga^*

来源：Journal of Medicinal Food, 2010, 13(5): 1176-1181.

DOI：10.1089/jmf.2009.0218

• antioxidant activity
• caryophyllene oxide
• 1,8-cineole
• essential oil
• Nepeta nuda spp. nuda
• 4a alpha,7 alpha,7 alpha beta-nepetalactone

Essential oils from air-dried leaves and verticillasters of Nepeta nuda ssp.nuda from Greece were analyzed by means of gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. The dominant constituent in the verticillaster oils was 4a alpha, 7 alpha, 7a beta-nepetalactone (75.7%). The main metabolites of the leaf oil were 1,8-cineole (16.7%), 4a alpha, 7 alpha, 7a beta-nepetalactone (24.7%), and caryophyllene oxide (16.3%). The oils were examined for their antioxidant activity. Neutralization of stable 2,2-diphenyl-1-picrylhydrazyl radical ranged from 10.83% (2.50 mu g/mL) to 58.64% (50.00 mu g/mL) for verticillaster oil and from 6.25% (2.50 mu g/mL) to 57.79% (50.00 mu g/mL) for leaf oil. The essential oil from verticillasters had significant effects on lipid peroxidation (in the range of 41.18-59.23%), compared to tert-butylated hydroxytoluene (37.04%). In contrast, the essential oil from leaves exhibited pro-oxidant activity at the highest concentration applied.

• 出版日期2010-10