Determination of endocrine-disrupting chemicals in human milk by dispersive liquid-liquid microextraction

作者：Vela Soria Fernando^*; Jimenez Diaz Inmaculada; Diaz Caridad; Perez Jose; Maria Iribarne Duran Luz; Serrano Lopez Laura; Pedro Arrebola Juan; Fatima Fernandez Mariana; Olea Nicolas

来源：Bioanalysis, 2016, 8(17): 1777-1791.

DOI：10.4155/bio-2016-0073

• dispersive liquid-liquid microextraction
• endocrine-disrupting chemicals
• human milk

Aim: Human populations are widely exposed to numerous so-called endocrine-disrupting chemicals, exogenous compounds able to interfere with the endocrine system. This exposure has been associated with several health disorders. New analytical procedures are needed for biomonitoring these xenobiotics in human matrices. A quick and inexpensive methodological procedure, based on sample treatment by dispersive liquid-liquid microextraction, is proposed for the determination of bisphenols, parabens and benzophenones in samples. Results: LOQs ranged from 0.4 to 0.7 ng ml(-1) and RSDs from 4.3 to 14.8%. Conclusion: This methodology was satisfactorily applied in the simultaneous determination of a wide range of endocrine-disrupting chemicals in human milk samples and is suitable for application in biomonitoring studies.

• 出版日期2016-9