Dose-dependent effect of glucose on GLP-1 secretion involves sweet taste receptor in isolated perfused rat ileum

作者：Xu, Zhiwei; Wang, Wendong; Nian, Xiaofeng; Song, Guiqin; Zhang, Xiaoyun; Xiao, Hongyuan; Zhu, Xiaobo^*

来源：Endocrine Journal, 2016, 63(12): 1141-1147.

DOI：10.1507/endocrj.EJ16-0390

• Sweet taste receptor
• Glucagon-like peptide 1
• Glucose concentration
• Rat
• Ileum

Luminal glucose is an important stimulus for glucagon-like peptide 1 (GLP-1) secretion from intestinal endocrine cells. However, the effects of luminal glucose concentration on GLP-1 secretion remain unknown. In this study, we investigated the effect of luminal glucose concentrations (3.5, 5, 10, 15, and 20 mmol/L) on GLP-1 secretion from isolated perfused rat ileum. Results showed that the perfusate glucose concentration dose-dependently stimulated GLP-1 secretion from isolated perfused rat ileum, which was eliminated by the sweet taste receptor inhibitor gurmarin (30 mu g/mL), but not inhibited by phloridzin (1 mmol/L), a Na+-coupled glucose transporters inhibitor. We conclude that luminal glucose induced GLP-1 secretion from perfused rat ileum in a concentration-dependent manner. This secretion was mediated by sweet taste receptor transducing signal for GLP-1 release on the gut of rat.

• 出版日期2016-12
• 单位河北大学