APOE epsilon 4 influences beta-amyloid deposition in primary progressive aphasia and speech apraxia

作者：Josephs Keith A^*; Duffy Joseph R; Strand Edythe A; Machulda Mary M; Senjem Matthew L; Lowe Val J; Jack Clifford R Jr; Whitwell Jennifer L

来源：Alzheimer's and Dementia, 2014, 10(6): 630-636.

DOI：10.1016/j.jalz.2014.03.004

• Apolipoprotein
• Pittsburgh compound B
• Primary progressive aphasia
• Logopenic aphasia
• Speech apraxia

Background: Apolipoprotein E epsilon 4 (APOE epsilon 4) is a risk factor for beta-amyloid deposition in Alzheimer's disease dementia. Its influence on beta-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear.
Methods: One hundred thirty subjects with PPA or progressive speech apraxia underwent APOE genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between APOE epsilon 4 and PiB status, as well as severity and regional distribution of PiB, was assessed.
Results: Forty-five subjects had an APOE epsilon 4 allele and 60 subjects were PiB-positive. The odds ratio for a subject with APOE epsilon 4 being PiB-positive compared with a subject without APOE 64 being PiB-positive was 10.2 (95% confidence interval, 4.4-25.5; P <.0001). The APOE epsilon 4 allele did not influence regional PiB distribution or severity.
Conclusion: APOE epsilon 4 increases the risk of beta-amyloid deposition in PPA and progressive speech apraxia but does not influence regional beta-amyloid distribution or severity.

• 出版日期2014-11