Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives

作者：Carvalho Samir A; da Silva Edson F; Lourenco Maria C S; de Souza Marcus V N; Fraga Carlos A M^*

来源：Letters in Drug Design and Discovery, 2010, 7(8): 606-609.

• 1,3,4-thiadiazoles
• Antimycobacterial activity
• N-arylhydrazones
• Tuberculosis

In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in mu g/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 mu g/mL and 1.25 mu g/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.

• 出版日期2010-10