A pregnancy lifestyle intervention to prevent gestational diabetes risk factors in overweight Hispanic women: a feasibility randomized controlled trial

作者：Hawkins M; Hosker M; Marcus B H; Rosal M C; Braun B; Stanek E J III; Markenson G; Chasan Taber L^*

来源：Diabetic Medicine, 2015, 32(1): 108-115.

DOI：10.1111/dme.12601

AimsTo pilot the feasibility of a prenatal lifestyle intervention to modify physical activity and diet among pregnant overweight and obese Hispanic women, with the aim of reducing risk factors for gestational diabetes mellitus.
MethodsWomen were randomized either to a lifestyle intervention (n=33, 48.5%), consisting of a culturally and linguistically modified, motivationally targeted, individually tailored 6-month prenatal programme, or to standard care (n=35, 51.5%). Bilingual and bicultural health educators encouraged women to achieve guidelines for physical activity, decrease saturated fat and increase dietary fibre. Outcomes included gestational weight gain, infant birth weight and biomarkers associated with insulin resistance.
ResultsPatient retention up to delivery was 97% in both study groups. The lifestyle intervention attenuated the pregnancy-associated decline in moderate-intensity physical activity, but differences between groups were not significant (meanse -23.416.6 vs -27.016.2 metabolic equivalent of task h/week; P=0.88). Vigorous-intensity activity increased during the course of pregnancy in the lifestyle intervention group (meanse 1.60.8 metabolic equivalent of task h/week) and declined in the standard care group (-0.8 +/- 0.8 metabolic equivalent of task h/week; P=0.04). The lifestyle intervention group also had slightly lower gestational weight gain and infant birth weights compared with the standard care group; however, these differences were not statistically significant. There were no statistically significant differences in biomarkers of insulin resistance between groups.
ConclusionsFindings suggest that a motivationally matched lifestyle intervention is feasible and may help attenuate pregnancy-related decreases in vigorous physical activity in a population of overweight and obese Hispanic women. The intervention protocol can readily be translated into clinical practice in underserved and minority populations.
What's new?
Although lifestyle changes have been effective in delaying or preventing subsequent Type 2 diabetes in non-pregnant women, few interventions have been used to test whether making changes in physical activity and diet during pregnancy can prevent risk factors for gestational diabetes mellitus. Our findings suggest that a motivationally matched lifestyle intervention is feasible and may help attenuate pregnancy-related decreases in vigorous physical activity in a population of overweight and obese Hispanic women. The intervention protocol can readily be translated into clinical practice in underserved and minority populations.

• 出版日期2015-1