A Convenient and Efficient Synthesis of Heteroaromatic Hydrazone Derivatives via Cyclization of Thiosemicarbazone with omega-Bromoacetophenone

作者:Liu Weiwei*; Tao Chuanzhou; Tang Lijuan; Li Jie; Jin Yan; Zhao Yueqiang; Hu Hongwen
来源:Journal of Heterocyclic Chemistry, 2011, 48(2): 361-364.
DOI:10.1002/jhet.585

摘要

The synthesis of hydrazone derivatives containing thiazole unit was achieved with condensation of thiosemicarbazones and omega-bromoacetophenone at room temperature. This mild, convenient, and efficient method affords the desired products with good to excellent yields. Their structures have been determined by X-ray diffractional analysis, (1)H-NMR, MS, elemental analysis, and IR. Thiosemicarbazones were prepared by the condensation of thiosemicarbazide with aldehydes or ketones.