Association of Neglect-Like Symptoms with Anxiety, Somatization, and Depersonalization in Complex Regional Pain Syndrome

作者：Michal Matthias; Adler Julia; Reiner Iris; Wermke Andreas; Ackermann Tatiana; Schlereth Tanja; Birklein Frank^*

来源：Pain Medicine, 2017, 18(4): 764-772.

DOI：10.1093/pm/pnw214

• CRPS
• Pain Disorder
• Psychology
• Neglect

Background. Many patients with complex regional pain syndrome (CRPS) report some foreignness of the affected limb, which is referred to as " neglectlike symptoms" (NLS). Despite similarities of the NLS reports to symptoms of body image disturbances in mental disorders, no study has been conducted to examine such associations.
Methods. We investigated 50 patients with CRPS and 45 pain control patients (N=27, chronic limb pain; N=18, migraine headache). NLS, anxiety, depression, depersonalization, and somatization were assessed using validated questionnaires.
Results. Seventy-two percent of the CRPS patients reported at least one NLS vs 29.6% and 33.3% in the two patient control groups. In limb pain controls, NLS correlated with pain intensity. In CRPS patients, NLS correlated with anxiety (rho50.658, P<0.001), somatization (rho50.616, P<0.001), depersonalization (rho50.634, P<0.001), and pain catastrophizing (rho50.456, P<0.01), but not with intensity of pain, duration of pain, or pain disability.
Conclusions. In CRPS patients, NLS could be a result of somatization, depression, anxiety, and depersonalization, but probably not of pain. Whether these associations are causative must be clarified in longitudinal psychological studies.

• 出版日期2017-4