An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding

作者：Moon Mi Eun; Choi Younghwa; Lee Young Min; Vajpayee Vaishali; Trusova Marina; Filimonov Victor D^*; Chi Ki Whan

来源：Tetrahedron Letters, 2010, 51(51): 6769-6771.

DOI：10.1016/j.tetlet.2010.10.099

• Arenediazonium tosylate salt
• Solvent-free grinding
• Halogenation

An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.

• 出版日期2010-12-22
• 单位香港理工大学