Delayed granulomatous reactions to facial cosmetic injections of polymethylmethacrylate microspheres and liquid injectable silicone: A case series

作者：Friedmann Daniel P^*; Kurian Anil; Fitzpatrick Richard E

来源：Journal of Cosmetic and Laser Therapy, 2016, 18(3): 170-173.

DOI：10.3109/14764172.2015.1114642

• Fillers
• silicone
• polymethylmethacrylate microspheres
• granulomas

Polymethylmethacrylate microsphere (PMMA) and liquid injectable silicone (LIS) fillers are nonbiodegradable, synthetic polymers utilized for long-term soft-tissue augmentation. Delayed granulomatous reactions to permanent fillers are a rare yet significant event that can occur months to years post procedure and are often refractory to treatment and associated with significant cosmetic morbidity. We report a case series of 4 patients who developed granulomatous reactions to PMMA or LIS, 15 months to 5 years post injection. The etiology of granulomatous reactions to permanent fillers is still poorly understood, with foreign-body reactions and/or biofilms purported to play a role. Real-time biochemical analysis with polymerase chain reaction should be performed when the index of suspicion for the presence of a biofilm is high.

• 出版日期2016