Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison

作者：Roh Daeyoung; Chang Jhin Goo; Yoon Sol; Kim Chan Hyung^*

来源：Clinical Psychopharmacology and Neuroscience, 2015, 13(3): 275-282.

DOI：10.9758/cpn.2015.13.3.275

• Schizophrenia
• Antipsychotic agents
• Polypharmacy
• First episode
• Antimanic agents

Objective: Early treatment choice is critical in first episode schizophrenia spectrum disorders. The purpose of this study was to describe prescribing trends of antipsychotics use in patients with first episode schizophrenia in 2005 and 2010, respectively.
Methods: We reviewed the medical records of newly treated patients with schizophrenia from a university psychiatric hospital in 2005 (n=47) and 2010 (n=52). We defined patients as receiving a high antipsychotic dose if their ratio of prescribed daily dose (PDD) to defined daily dose (DDD) was greater than 1.5.
Results: The rates of high dose antipsychotic prescription were 61.7% and 53.8% in 2005 and 2010, respectively. The rates of antipsychotic polypharmacy were 34.6% in 2005 and 34.0% in 2010. The most common first prescribed antipsychotics were (in descending order of prescription frequency) olanzapine, risperidone, aripiprazole, and haloperidol in 2005 and risperidone, quetiapine, paliperidone, and olanzapine in 2010. High dose antipsychotics were significantly associated with antipsychotic poly
pharmacy (odds ratio=23.97; p<0.01). More individuals were treated with mood stabilizers in 2010 than in 2005 (p=0.003). Conclusion: The practice of prescribing high dose antipsychotics and associated antipsychotic polypharmacy were common even for initial treatment of first episode schizophrenia in 2005 and 2010. In 2010, the list of the most common first prescribed antipsychotics changed, and the use of mood stabilizers increased in non affective schizophrenia.

• 出版日期2015-12