Gliosarcoma arising from a fibrillary astrocytoma

作者：Kobayashi Tatsuya; Sakai Keiichi^*; Tada Tsuyoshi; Sekiguchi Yasuyuki; Hara Yosuke; Kodama Kunihiko; Goto Tetsuya; Tanaka Yuichiro; Sano Kenji; Nakayama Jun; Hongo Kazuhiro

来源：Journal of Clinical Neuroscience, 2011, 18(9): 1251-1254.

DOI：10.1016/j.jocn.2010.07.152

• Brain neoplasm
• Diffuse astrocytoma
• Gliosarcoma
• Malignant transformation

We report a 67-year-old woman who was diagnosed with a gliosarcoma at a second operation after diagnosis of a fibrillary astrocytoma 5 months previously. Initially, she underwent a CT-guided stereotactic biopsy. Histological examination showed fibrillary astrocytoma (World Health Organization [WHO] grade II). Loss of heterozygosity (LOH) on 1 p, 10q, and 19q was not detected. She received chemotherapy, but no radiotherapy. Five months after the biopsy, MRI revealed rapid tumor growth. Tissue obtained from partial removal of the tumor revealed gliosarcoma (WHO grade IV), and LOH on 10q and 19q was detected. The history, histopathology, and genetic alterations of this patient are discussed.

• 出版日期2011-9