科研之友
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摘要
Molecular imaging provides a powerful tool for early disease detection, characterization, and real-time monitoring of therapeutic responses. Central to molecular imaging is the development of imaging probes. Receptors that are over-expressed in tumors have been potential targets for cancer imaging using targeted molecular probes. Since many cancer types simultaneously overexpress several receptors, the design of dual receptor-targeted molecular imaging probes has recently been proposed. Peptide heterodimers, and microbubble-based dual-targeted probes have shown especially good performance for in vivo cancer imaging. The success of these molecular probes demonstrates that the dual-targeting strategy is generally a good approach for developing molecular probes. In this review, we will introduce the current state of development of dual-targeted molecular imaging probes and summarize the various dual-targeted molecular probes for in vivo cancer imaging.
- 出版日期2010-9
- 单位北京大学
