Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes

作者：Suh Jin Soon; Kim Shin Hee; Cho Kyoung Soon; Jung In Ah; Cho Won Kyoung; Jeon Yeon Jin; Jung Min Ho; Suh Byoung Kyu

来源：Pediatric Nephrology, 2016, 31(4): 623-631.

DOI：10.1007/s00467-015-3253-9

• Liver-type fatty acid binding protein
• YKL-40
• Albuminuria
• Biomarkers
• Diabetic nephropathy
• Children

Background The aim of this study was to evaluate the association of a urinary tubular marker, liver-type fatty acid binding protein (L-FABP) and an inflammatory marker, serum/urinary YKL-40, with albuminuria in patients with childhood-onset type 1 diabetes (T1D).
Methods Twenty-nine patients with childhood-onset T1D and 32 controls were enrolled. Serum and urinary concentrations of YKL-40 and urinary concentrations of L-FABP were measured.
Results The serum levels of YKL-40 were not significantly different between the control group and the patient groups. However, the levels of urinary YKL-40/creatinine (Cr) were higher in the patients, even those with normoalbuminuria than in the controls (p< 0.001). The levels of urinary L-FABP/Cr were not different between the control group and the patient groups. However, the level of urinary L-FABP/Cr in the microalbuminuria group was higher than that in the normoalbuminuria group (p= 0.03). There were no associations between the levels of urinary albumin-to-creatinine ratio and urinary L-FABP/Cr or YKL-40/Cr. However, the urinary L-FABP/Cr level was significantly correlated with the hemoglobin A1C level (p= 0.005) and the urinary YKL-40/Cr level (p= 0.043).
Conclusions Urinary L-FABP/Cr and YKL-40/Cr may reflect renal injury in early stages of nephropathy in patients with childhood-onset T1D, even in the normoalbuminuric state.

• 出版日期2016-4