Angiomatoid Fibrous Histiocytoma of Bone: A Calcifying Sclerosing Variant Mimicking Osteosarcoma

作者：Mangham David Chas^*; Williams Ann; Lalam Radhesh K; Brundler Marie Anne; Leahy Michael G; Cool Wim Paul

来源：American Journal of Surgical Pathology, 2010, 34(2): 279-285.

• angiomatoid fibrous histiocytoma
• bone tumor
• EWSR1
• ATF1
• osteosarcoma

Angiomatoid fibrous histiocytoma is a neoplasm of uncertain histogenesis, which most commonly arises ill the subcutaneous tissue of the extremities of children and young adults. We report the first case of a calcifying sclerosing variant of this entity. This case arose in bone-a site where there has been just I previously published case of typical (nonsclerosing/mineralizing) angiomatoid fibrous histiocytoma. The patient presented with the classical paraneoplastic syndrome that call Occur with this tumor type and, apart from the described extracellular matrical features, displayed typical histologic features. Due to the rarity of angiomatoid fibrous histiocytoma at this site and the presence of matrical sclerosis/mineralization, this case raised the important differential diagnosis of osteosarcoma, both histologically and radiologically. The diagnosis was confirmed by Molecular analysis: fluorescence in situ hybridization for EWSR1 gene disruption, and reverse transcription-polymerase chain reaction using newly designed primers on both frozen and decalcified, paraffin-embedded tissue samples showing an EWSR1-ATF1 translocation. It is important to recognize that this relatively indolent tumor call arise in bone and that it can contain focally mineralized hyalinized sclerotic matrix to avoid making the serious misdiagnosis of high-grade osteosarcoma and administering aggressive systemic chemotherapeutic treatment.

• 出版日期2010-2